Of mortality (p = 0.62). Significant differences in the echocardiograp…
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Of mortality (p = 0.62). Significant differences in the echocardiographic parameters were found between the case and control group (Table 2) however AFib remained significantly associated with mortality after adjustments for conventional echocardiographic parameters of forward and backward failure (Table 3). Similarly, AFib remained significantly associated with mortality (hazard ratio 1.78, 95 confidence interval: 1.10?.91; p < 0.02) after adjustment for mitral regurgitation (p = 0.80).DiscussionAtrial fibrillation predicts mortality in aortic stenosisIn this study we analyzed echocardiographic examinations from 103 patients with AS and AFib and compared them with 103 controls (with AS but and SR) matched on age, gender and severity of AS. We found that patients with coexistence of AS and AFib had significantly higher risk of death compared to controls (Figure 1). This difference remained after adjustment for LVEF, left atrialBurup Kristensen et al. Cardiovascular Ultrasound 2012, 10:38 http://www.cardiovascularultrasound.com/content/10/1/Page 4 ofTable 1 Population characteristics at baselineCONTROLS Aortic stenosis sinus rhythm Age , years Male gender, n ( ) Body Mass Index, kg/m2 Body Surface Area, m Heart Methyl 2-((4-nitro-1h-pyrazol-1-yl)methyl)benzoate rate (bpm) Cardiovascular risk factors and co-morbidities Hypertension, n ( ) Smoking (previous or current), n ( ) Peripheral vascular disease, n ( ) Diabetes (Type I or II), n ( ) Hypercholesterolemia, n ( ) Stroke, n ( ) Ischaemic heart disease, n ( ) Familiar disposition, n ( ) Chronic lung disease, n ( ) Medication -blockers, n ( ) Calcium-antagonists, n ( ) ACE-inhibitors and/or Angiotensin-II-receptor-antagonists, n ( ) Diuretics (any kind), n ( ) Loop-diuretics, n ( ) Thiazides, n ( ) Potassium-sparing diuretics, n ( ) Insuline, n ( ) Oral antidiabetics, n ( ) Statins, n ( ) Aspirin, PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/3081428 n ( ) Warfarin, n ( ) Digoxin, n ( ) Amiodarone, n ( ) Operative risk calculations Additive EuroSCORE Additive EuroSCORE without LV PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/1435082 dysfunction Symptoms Symptoms (angina pectoris, dyspnea, dizziness, syncope), n ( ) Angina pectoris, n ( ) Dyspnea, n ( ) Dizziness, n ( ) Syncope, n ( ) 75 43 59 12 5 (77) (43) (63) (13) (5) 87 28 80 17 9 (86) (28) (80) (17) (9) 0.08 0.02 0.008 0.41 0.31 8 7 (7?0) (6?) 9 7 (7?0) (6?) 0.05 0.39 37 21 42 46 19 27 6 11 10 51 57 5 0 0 (41) (23) (47) (51) (21) (30) (7) (12) (11) (57) (63) (10) (6) 58 22 38 65 51 15 9 3 14 48 50 11 59 45 2 (58) (22) (38) (65) (51) (15) (9) (3) (14) (48) (50) (11) (59) (45) (2) 0.02 0.83 0.23 0.05 <0.001 0.013 0.55 0.02 0.55 0.23 0.06 0.82 <0.001 <0.001 0.18 57 57 5 22 47 15 27 14 22 (57) (64) (5) (21) (49) (15) (26) (18) (21) 55 65 13 25 46 14 34 16 17 (55) (72) (16) (24) (46) (15) (33) (22) (17) 0.78 0.24 0.02 0.62 0.63 0.94 0.29 0.49 0.CASES Aortic stenosis atrial fibrillation 78 70 25.5 1.89 81 (73?4) (68) (22.3?7.5) (1.75?.06) (73?6)P-value78 70 25.7 1.88(73?4) (68) (22.3?8.1) (1.76?.06) (63?7)0.96 1.00 0.65 0.90 <0.Inhaled Medications (glucocorticoids/anticholinergics/2-agonists), n ( )volume, maximal tricuspid valve regurgitation, estimated right atrial pressure, estimated systolic pulmonary artery pressure and E/e' (Table 3). A few studies have described an increased mortality in patients with AS and AFib undergoing surgical intervention [11-14], 5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile and one studybased on a selected population have found an increased risk of heart failure and non-hemorragic stroke in AS and AFib. The same study also found that new-onset AFib was associated with cardiac decompensation [10]. More.
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